Echinoclasterol sulfate

Echinoclasterol sulfate phenethylammonium salt (585), an antifungal and cytotoxic steroid, was isolated from the South Australian sponge Echinoclathria subhispida [472]. 

P-Monosulfated derivatives are less frequent than the monosulfated derivatives mentioned above, and some of them have quaternary ammonium as the counterion, such as echinoclasterol sulfate, which is associated with the (3-phenylethylammonium cation. 

Northcote, and Webb, 2002). Echinoclathria subhispida contains echinoclasterol sulfate, a polyhydroxylated sterol monosulfated at 2p, whose counterion is P-phenylethy-lammonium (see above) (Li et al, 1993). Clathsterol is a new 2p,3a- disulfated sterol which has anti-HIV-1 properties it was isolated from an undetermined species of the genus Clathria harvested in the Red Sea, in the Dahlak Archipelago (Rudi et al, 2001). This type of polyhydroxylated and sulfated sterol is common among halichondrid sponges (see above). 

Li, H.-Y, Matstmaga, S., Fusetani, N Fujiki, H Murphy, P.T., Willis, R.H., and Baker, J.T. (1993) Echinoclasterol sulfate phenethylammonimn salt, a unique steroid sulfate from the marine sponge Echinoclathria subhispida. Tetrahedron Lett., 34, 5733-5736. 

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