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Ecdysteroid agonists bisacylhydrazines

Fig. 25.1.1. Chemical structures of 20-hydroxyecdysone (20E 1 R] = OH), the first bisacylhydrazine found to have an ecdysone agonist effect in insect assays (2), and the first bisacylhydrazine (RH-5849 3) well characterized for its ecdysone effects at cellular and whole insect level, as well as binding to Drosophila melanogaster ceW extracts containing ecdysteroid receptor complexes. Numbers on the 20E structure represent the carbon-numbering system. Fig. 25.1.1. Chemical structures of 20-hydroxyecdysone (20E 1 R] = OH), the first bisacylhydrazine found to have an ecdysone agonist effect in insect assays (2), and the first bisacylhydrazine (RH-5849 3) well characterized for its ecdysone effects at cellular and whole insect level, as well as binding to Drosophila melanogaster ceW extracts containing ecdysteroid receptor complexes. Numbers on the 20E structure represent the carbon-numbering system.
In considering the SAR of bisacylhydrazines for the discovery of new and novel ecdysone agonists, it is essential to understand the SAR of ecdysteroids. This helps to define the three-dimensional (3D) space of ecdysteroids in the EcR LBD and allows for overlaps and comparison with BAH or other ecdysone agonist chemotypes (described below). [Pg.779]

See other pages where Ecdysteroid agonists bisacylhydrazines is mentioned: [Pg.16]    [Pg.22]    [Pg.179]    [Pg.909]    [Pg.915]    [Pg.782]    [Pg.56]    [Pg.182]    [Pg.190]    [Pg.56]    [Pg.773]   
See also in sourсe #XX -- [ Pg.22 ]

See also in sourсe #XX -- [ Pg.22 ]

See also in sourсe #XX -- [ Pg.22 , Pg.29 ]



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