Erythromycin Ebastine

Cardiac effects were reported from early experimental work using very high doses of ebastine, but they are not believed to be clinically relevant in normal use. In one study serial electrocardiograms showed no changes with doses up to the maximum used (30 mg). Ebastine in doses up to five times the recommended therapeutic dose did not cause clinically relevant changes in QTc interval in healthy subjects (2). Co-administration of ebastine with ketoconazole or erythromycin did not lead to significant changes in the QTc interval (3,4). 

Only a modest increase in QTc interval has been observed with concomitant use of erythromycin and the antihistamine ebastine (91). 

Erythromycin modestly raises mizolastine levels, althongh this had no effect on the QT interval. Nevertheless, the mannfactnrers of mizolastine contraindicate er3i hromycin. Erythromycin markedly raised ebastine levels, which caused a modest prolongation of the QT interval. The manufacturers of ebastine advise against the... 

The manufacturers of mizolastine also contraindicate the concurrent use of the macrolides, despite any evidence of a significant interaction. Erythromycin markedly raises ebastine levels causing a modest increase in QT interval. The manufacturer of ebastine advises against concurrent use of the macrolides erythromycin, clarithromycin and josamycin." Erythromycin also raises loratadine levels, which caused a very slight increase in QTc interval in one study. However, no special precautions appear to have been recommended for the use of loratadine with macrolides. Because there are no data on acrivastine with erythromycin, the manufacturer advises caution. ... 

Ebastine 20 mg daily Erythromycin 2.4 g daily 10 30 healthy subjects 1 19% Similar changes found for carebastine 164% Similar changes found for carebastine Mean increase of 19.6 milliseconds 6... 

Gillen M, Pentikis H, Rhodes G, Chaikin P, Morganroth J. Pharmacokinetic (PK) and pharmacodynamic (PD) interaction of ebastine (EBA) and erythromycin (ERY). Clin... 

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