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Easy Construction of a Tricyclic Indole Related to the Mitomycins

Easy Construction of a Tricyclic Indole Related to the Mitomycins [Pg.88]

As part of a programme of studies on the synthesis of mitomycins, the dione 1 was treated with sodium hydride in dry THF at room temperature. This gave an epimeric mixture of carbinolamines which was highly acid sensitive and which, on treatment with glacial acetic acid at room temperature for 5 minutes, underwent dehydration to the tricyclic indole derivative 2. [Pg.88]



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A- -indole

A- indoles

Indole, tricyclic

Mitomycin

Mitomycin A

Of indole

Of indoles

Of mitomycin

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