Early delivery

The likelihood of a successful resuscitation outcome is enhanced if each of four critical elements in the chain of survival is implemented promptly (1) early recognition of the emergency and activation of emergency medical services (2) early bystander basic life support and CPR (3) early delivery of a shock with a defibrillator and (4) early ACLS followed by resuscitation care delivered by healthcare professionals. 

To begin with, we believe in early delivery of prototypes and vertical slices, as you ll see from the How to chapters in Part V And understanding what it is you are building is a major part of the real job of writing the code, and it is a lot more effective than just getting in there and hacking.3... 

What information will be extracted and fed back to analysis from an early delivery ... 

Other studies evaluated the question of whether early delivery of radiation concurrently with chemotherapy was better than late delivery. A study performed by the C ALGB randomized patients to early (d 1, cycle 1), late (d 64, cycle 4), or no radiation therapy. The radiation therapy dose was 50 Gy over 6 wk. Chemotherapy used in this trial was cyclophosphamide, etoposide, and vincristine. The local recurrence rate for the early, late, and no radiation therapy arms was 49%, 68%, and 82%, respectively. The 2-yr progression-free survival rate was 15% for the early schedule arm vs 25% for the late schedule (p = 0.078). The 5-yr survival rate for the early, late, and no radiation therapy arms was 6.6%, 12%, and 3%, respectively (p = 0.007). The poor 5-yr survival rate for the early schedule was felt to be due to the significant decrease in chemotherapy dose needed for the early schedule group (4,49). 

Current data support the use of concurrent over sequential or alternating chemotherapy and radiation therapy. The optimal delivery of concurrent chemoradiation is still under study. Early delivery of radiation therapy may decrease dissemination by killing the chemoresistant tumor cells prior to their distant seeding. Late delivery of radiation therapy possibly reduces toxicities and full chemotherapy doses can be delivered. However, even with increased toxicity, improved survival rates help establish as standard early delivery of concurrent radiation with platinum-based chemotherapy. 

Early deliveries (see definitions in Note 6) Infants are euthanized and processed according to protocol in the same way as fetuses. 

Design implications Set high service levels Set medium service levels Negotiate early delivery of... 

Pregnancy complications, including ectopic (tubal) pregnancy and preterm (early) delivery. 

Cancers only account for about half of the smoking-related deaths. Smoking is a major cause of bronchitis, emphysema, heart disease, and stroke. Tobacco is associated with female reproductive health, increases in miscarriage rates, early delivery, stillbirth, infant death, and low birth rate. It is estimated that 9 million Americans suffer from tobacco-related illnesses at any given time. ... 

It is related to abnormal endothelial reactivity that leads to intravascular deposition of fibrin with subsequent end-organ damage. Most maternal deaths are due to central nervous system complications, but the liver may also be the target of injury. The injury to the liver is ischemic. Modest elevations in ALT and AST occur, typically 4 to 10 times the upper reference limit. Hepatic complications, including hemorrhage, infarction, and fulminant hepatic failure, may occur and necessitate early delivery... 

Delivery of aerosols to patients on ventilators has received much attention since the early 1990s. Some studies of early delivery techniques documented low (2.2%) deposition in the lung, with half retained in the nebulizer, and considerable intersubject variability [80]. While the primary focus of this discussion will be on aerosol delivery to ventilated patients, assessing efficacy of aerosol medications to ventilator patients is very difficult. 

Funding for the production studies of this mask is included in the budget for the fiscal year 1961. This is in the amount of 500,000. To assure an early delivery, we have recently made 100,000 available to the Chemical Corps to begin these studies prior to the time the 500,000 will be available which should be the latter part of August or early September. 

Effective and efficient utilization of assets by pharmaceutical research or manufacturing enterprises is fundamental to the early delivery of new products to market and to satisfying customer demand once those products have been approved for release by the relevant regulatory authorities. Effectiveness and efficiency must be established from the outset of asset specification and design ("built-in quality") and cannot be delivered by fine tuning and testing ("testing in quality") when the asset is handed over from the development environment to the operational environment. Assets must be reliable, consistent and capable, that is, they must... 

Seasonality must be considered when applicable. For some products, sales volumes peak at certain times of the year (such as toy sales at Christmas) in other cases, raw materials, such as fresh fruits and vegetables, may only be available at specific times. Both cases require out of-season storage. Manufacturers must invest in warehouses, use third parties, or provide incentives to intermediaries so they perform the storage function. For example, manufacturers might offer a seasonal discount or consignment inventories to wholesalers or retailers who agree to take early delivery. 

Furthermore, the actions taken after monitoring outcomes are as important as the monitoring itself. A signal of distress often leads to early delivery induction (Haws et al., 2009). Moreover, it is important that the conclusions drawn from the monitoring outcomes are accurate enough to prevent unnecessary early deliveries. 

Consider a supply chain of three levels in series shown in Fig. 3.10. The first and most upstream level (Level 1) has two factories in parallel producing two major products, FI and F2, in full production capacity of 168 h (24 x 7) a week. They both feed a distribution center (DC) in Level 2 and deliver to a common customer in Level 3. Products can also be delivered to the customer by the distribution center. Both factories have no room for finished goods storage and the customer does not want to receive any early deliveries. The medium term planning production timing and quantities that minimizes the total cost of production cost, storage cost, transportation cost, tardiness cost for the whole supply chain over a 4 week time horizon, (the unit of time being one week). The transportation time from any one of the two factories to the DC, firom any one of the two factories to the customer, and from the DC to the customer all transportation times are assumed to be identical and equal to one week. 

In an n-firm market game in which firms compete for orders by early delivery, Li [95] considers the effect of inventory in such competition. He shows that firms are more likely to keep inventory in such a market with competition. 

Deliver timely shipments Early dehvery can be as harmful to the company s future as late delivery, because buyers then must accommodate early deliveries with additional storage capacity. Ideally, the planning should allow for exact delivery when the customer demands. At the same time, there must be sufficient labor and raw material delivery in the exact proportions to meet the deadlines without having to pay extra for overtime. 

STONE, an element of WTF, and in answer to Shadle s request, ordered 16,000 smoke pots and 11,300 incendiary grenades shipped to England for early delivery to CTF. While the number of smoke pots was inadequate from Shadle s point of view, the shipment at least denoted the firm intention of providing smoke cover for the debarkation ports. This port concealment operation was one the CWS had not previously attempted. 

Sacral rocking may be used to release sacral restrictions, both before delivery and during early delivery (Fig. 116-8). After delivery, the woman s legs are removed from the stirrups and her hips are put through adduction and internal rotation while still flexed, followed by extension (Figs. 116-9 and 116-10). This reduces the po-... 

Amniotic fluid palmitic acid can be measured as an indication of fetal lung maturity as an alternative to lecithin-sphingomyelin ratios (q.v.). This is because palmitic acid is a component of the lecithin molecule. High amniotic fluid palmitic acid levels indicate fetal lung maturity and enable early delivery of the infant to be contemplated. Palmitic acid can be estimated by gas-liquid chromatography after hydrolysis of the lecithin to give the free fatty acid. 

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