E-NTPDase

The involvement of releasable enzymes in the metabolism of extracellular nucleotides has been suggested to explain an increase in the capacity to metabolize ATP observed in some tissues following nerve stimulation (Todorov et al. 1996 Mihaylova-Todorova et al. 2002). Released enzymes resembling the E-NTPDases mentioned above seem to be able to convert released ATP to AMP. In some tissues (guinea pig but not rabbit vas deferens), the released enzymes also hydrolyse AMP into adenosine (see Westfall et al. 2002). 

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