Dysalbuminemic hyperthyroxinemia

The function of most albumin isoforms is normal, although some have abnormal binding affinities for thyroxine (T4). Binding may be increased, as in familial dysalbu-minemic hyperthyroxinemia, or decreased. Individuals with famihal dysalbuminemic hyperthyroxinemia are euthyroid but have elevated serum T4 and free T4 index the variant albumin comigrates with Alb A. Two glycosylated variants. Alb RedhiU and Alb Casebrook, have altered fatty acid binding properties. 

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