Dynorphins biological activity

The Group III peptides come from the 256-amino acid precursor, pro-dynorphin [88402-55-5] (pro-enkephalin B). This group contains dynorphin A [80448-90-4] and B [85006-82-2] as weU as a-neoendorphin [77739-20-9] (Fig. 2), all of which can be further cleaved to form biologically active iatermediates, eg, dynorphin A g and P-neoendorphin [77739-21-0] (a-neoendorphin ) (28). The longer of these peptides are relatively basic because of the number of Lys and Arg residues. 

Goldstein A, Tachibana S, Lowney LI, et al. Procaine pituitary dynorphin complete amino acid sequence of the biologically active heptadecapeptide. Proc Natl Acad Sci USA 1979 76 6666-6670. 

A. Goldstein, S. Tachibana, L.I. Lowney, M. Hunkapiller, L. Hood, Dynorphin (1-13) an extraordinarily potent opioid peptide. Proc. Natl. Acad. Sci. U.S. 76 6666-6670 A. Goldstein, W. Fischli, L.I. Lowney, M. Hunkapiller, L. Hood, Porcine pituitary dynorphin complete amino acid sequence of the biologically active heptadecapeptide. ibid. 78 7219-7223 (1981)... 

Meyl995 Meyer, J.-R, Davis, R, Lee, K.B., Rorreca, F, Yamamura, H.I. and Hruby, V.J., Synthesis Using a Fmoc-Based Strategy and Biological Activities of Some Reduced Peptide Bond Pseudopeptide Analogues of Dynorphin A, J. Med. Chem., 38... 

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