Drying particle morphology

Figure 11 Potential spray-dried particle morphologies in relation to process conditions and material characteristics. (From Ref 17.)...

Fig. 6.16 Effect of addition of BSA and P-lactoglobulin on the spray-dried particle morphology (trehalose mass fraction 30%, ADH content 0.23 mg ADH/g trehalose, standard drying conditions).

Synthesis of composite particulates with tailored morphologies using dry particle coating... 

Crowder TM, Rosati JA, Schroeter JD, Hickey AJ, Martonen TB. Fundamental effects of particle morphology on lung delivery predictions of Stokes law and the particular relevance to dry powder inhaler formulation and development. Phanna Res 2002 19 239-245. 

Walton, D.E., and Mumford, C.J. (1999). Spray-dried products characterization of particle morphology. TransIchemE, 77A, 21-38. 

Some empirical observations can help to understand how the feedstock physical state (i.e., suspension, emulsion, solution) and the physicochemical properties of the formulation components relate to the morphology and surface characteristics of the spray dried particles. As mentioned above shell formation will occur when one of the formulation components reaches its solubility and precipitates leading to the formation of a solid shell that may be either amorphous or crystalline. Low aqueous solubility components tend to precipitate early in the drying process and lend to form corrugated... 

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