Drugs stereoselective synthesis

Stereoselective synthesis of (2Y,7Y)-7-(4-phenoxymethyl)-2-(l-iV-hydroxyureidyl-3-butyn l-yl)oxepane, as a potential antiasthmatic drug candidate, is described <2005TA935>. 

Astleford, B. A. Weigel, L. O., ResolutionVersus Stereoselective Synthesis in Drug Development Some Case Histories, in Ref. 10, pp. 99—117. 

Hydroxylation of sodium and potassium enolates side reaction with lithium Substrate controlled stereoselectivity asymmetric hydroxylation Asymmetric hydroxylation with camphor sultam derivatives Asymmetric synthesis of tetracycline precursors Synthesis of a calcium channel opening drug Asymmetric synthesis ofbuproprion Summary... 

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