Drugs polyether antibiotics

At present, liquid chromatography has become the most widely used technique for determining anticoccidial drugs in edible animal products (Table 29.11). The separation of these drugs is generally done on nonpolar reversed-phase columns (octadecyl, octyl and phenyl), the preferred type being the octadecyl bonded silica. However, polar (389, 390, 392, 398, 400) columns have also been used for the determination of the polyether antibiotics in edible animal products. 

Quantification of five different drugs in pigs kidney Separation of carboxylic polyether antibiotics (monensin, salinomycin, and narasin) with an amino bonded phase and 15% methanol in carbon dioxide using light-scattering detector Analysis of hydroxylated metabolites of dialkyldithio-carbamates... 

LC/MS has had a strong influence upon pharmaceutical chemistry for the analysis of both highly polar metabolites and their precursors, as described in the second section of this book. The technique has been used for the analysis of polypeptides and a variety of intractable pharmaceuticals such as tetracycline, -lactams, and polyether antibiotics. The structures of highly polar drug metabolites formed in vivo— including sulfate esters, glucuronides, taurine, and camotine... 

Table 3 lists the polyether antibiotics used as poultry anticoccidial drugs in the United States. Recendy, lasalocid and monensin have been approved... 

Like previous consumer safety studies with polyether antibiotics, the work reported here was undertaken to determine the tissue distribution, metabolic fate and depletion of residues of 14C-semduramicin sodium in broilers and to characterize the depletion of residues of the drug in poultry dosed under commercial use conditions. 

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