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DRUGS BASED ON A SUBSTITUTED BENZENE RING

Stobadine ((-)-cis-2,8 dimethyl-2,3,4,4a,5,9b-hexahydro-l-H-pyrido (4,3b) indole) is a model drug with pyridoindole structure with cardioprotective and antioxidant properties [109]. Based on stobadine, (-)-ris-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-lH-pyrido[4,3-b]indole (Fig. 4), a well-known antioxidant, free-radical scavenger and neuroprotectant, stobadine derivatives with improved pharmacodynamic and toxicity profiles were developed [110]. A stobadine molecule was modified mostly by electron donating substitution on the benzene ring and by alkoxycarbonyl substitution at N-2 position. Significant antioxidant activity was observed in the new compounds. A link... [Pg.154]

See other pages where DRUGS BASED ON A SUBSTITUTED BENZENE RING is mentioned: [Pg.43]    [Pg.44]    [Pg.46]    [Pg.48]    [Pg.50]    [Pg.52]    [Pg.54]    [Pg.56]    [Pg.58]    [Pg.60]    [Pg.62]    [Pg.64]    [Pg.66]    [Pg.68]    [Pg.70]    [Pg.72]    [Pg.74]    [Pg.76]    [Pg.78]    [Pg.80]    [Pg.82]    [Pg.84]    [Pg.86]    [Pg.88]    [Pg.43]    [Pg.44]    [Pg.46]    [Pg.48]    [Pg.50]    [Pg.52]    [Pg.54]    [Pg.56]    [Pg.58]    [Pg.60]    [Pg.62]    [Pg.64]    [Pg.66]    [Pg.68]    [Pg.70]    [Pg.72]    [Pg.74]    [Pg.76]    [Pg.78]    [Pg.80]    [Pg.82]    [Pg.84]    [Pg.86]    [Pg.88]    [Pg.448]    [Pg.441]    [Pg.69]    [Pg.253]    [Pg.194]   


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A ring substitutions

Bases Base substitution

Bases Benzene

Benzene ring, substitution

Benzene rings

Benzene rings Benzenes

Benzene rings substituted

Benzene substitution

Benzenic ring

Ring substitution

Substitution on

Substitution substituted benzenes

Substitutive drugs

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