Drug solubilization solubility properties

In investigating temperature effects on drug solubilization in micellarsystems, changes in the micellar properties as well as those in the aqueous solubility of the solute signiLcantly affect the solubilization... 

A drug molecule has to be water soluble to be readily delivered to the cellular membrane, but needs to be hydrophobic to cross the membrane (Thompson, 1997). Both properties can be utilized to develop various solubilization systems that can deliver water-insoluble drugs via various routes to the targets in humans. Through years of diligent and intelligent research by pharmaceutical scientists,... 

Solubilization oftropicamide, a poorly water-soluble mydriatic/cycloplegicdrug, by poloxamers or Pluronics was studied (Saettone et al., 1988). The polymers evaluated as solubilizers for the drug included L-64, P-65, F-68, P-75, F-77, P-84, P-85, F-87, F-88, and F-127. The authors measured a range of physicochemical properties, such as solubility oftropicamide in polymer solutions, partition coefLcient of the drug between isopropyl myristate and copolymer solutions, critical micelle concentration of the copolymers, and viscosity of the copolymeric solutions containing tropicamide. 

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