Drug solubility and biological activity

There should be a broad correlation between aqueous solubility and indices of biological activity. On the one hand, as dmg solubility in aqueous media is inversely related to the 

There are other examples in which aqueous solubility acts as a rough and ready guide to 

Spiro mycin Free bose Poorly soluble 9.4 0.8 

High molecular weight quaternary salts such as bephenium hydroxynaphthoate (XXI) and pyrvinium embonate (XXII), being quaternary, have low lipid solubility but also have 

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