Drug release pore distribution

The physical properties of pellets have been widely used to determine an acceptable yield of pellets. These include shape indices, size and size distribution, densities, pore volume and distribution, flow properties, and friability. Of course, drug release from the pellets is a critical parameter to be monitored in order to ensure potency and uniformity of drug distribution. 

Drug delivery systems have been developed for doxorubicin [51] (a drug used to treat leukemia but which has cardiac risk factors), and for flavors such as decanoic acid [52]. In both cases, the encapsulation efficiency as given by load, recovery speed and recovered quantity was assessed. In addition, the stabihty (shelf life) of such gel matrices in terms of stabihty of the pharmaceutically active ingredient was increased compared to their free form. Similar appHcations for coatings for the controlled release of biocides [53] and other pharmaceuticals such as vitamins [54] have also been made. Clearly, gel porosity, pore size distribution, temperature, pH all influence the release, and these parameters must be optimized. 

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