Drug release paddle dissolution

Six tablets were subjected to. dissolution using the USP dissolution apparatus (Vanderkamp 600, Van-Kel Ind., NJ, USA) in 500 ml buffer pH 1.2 (the first hour) and 650 ml buffer pH 6.8 (1-14 h), maintained at 37°C and rotated with paddles at 50 rev min-1 (first hour) and 130 rev min-1 (1-14 h). The dissolution apparatus was connected to a UV-visible spectrophotometer (Uvikon 810, Roxche Bioelectronique Kontron, Marseille) and a computer (VAX 780 Digital). The absorbance of the dissolution medium at 275 nm was recorded automatically at intervals (1, 2, 4, 5, 8, 10, 12 and 14 h). The percentage of the drug released was calculated and the corresponding release profiles were obtained. 

The in vitro drug release profile (USP drug dissolution method, paddle type) of 5-amino salicylic acid from various grades of CMS-g-PAM matrix, in neutral dissolution medium is shown in Figure 5.12 [47]. 

Some series of these systems were prepared at different compression force levels and drug release rate was checked by U.S.P. XX paddle dissolution method. 

For the dissolution testing of an amorphous dmg product, any of the test apparatus typically used for testing of solid oral dosage forms may be selected based on its demonstrated capability to provide meaningful drug-release data and to discriminate for critical factors. Typically, the basket and paddle apparatus are the most commonly used. However, the reciprocating cylinder apparatus and the fiow-through apparatus also may be used. 

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