Drug-polymer study

Formulation Preparation Method Drug Polymer Studies Comments Reference... 

Interaction between sulfathiazole and povidone was studied by Raman spectroscopy, and the nature of the drug-polymer coprecipitates investigated [51]. The nature of the drug (solvation state) and its bonding to the polymer were assessed with respect to sulfathiazole dissolution rate. 

The periodontal pocket is another site for drug delivery in the oral cavity. Needleman et al. [46] investigated three mucoadhesive polymers (cationic chitosan, anionic xanthan gum, neutral polyethylene oxide) in vitro, using organ cultures, and in vivo in patients on their periodontal and oral mucosa. Of the polymers studied, chitosan displayed the longest adhesion in vitro and on the periodontal pockets, and the shortest adhesion on oral mucosa. 

A simple picture of the structure of skin is to consider it as an interwoven mass of protein polymer chains containing channels and voids filled with aqueous matter. These channels in skin dermis are about 10 A in diameter (20). Many substances have been used to simulate skin in drug penetration studies, but they all have the disadvantage that little is known about their inherent structures. General examples illustrative of this fault are the common use of agar gels and cellulose films. 

Vasey, P. A., Kaye, S. B., Morrison, R., et al. Phase I clinical and pharmacokinetic study of PK1 [lV-(2-hydroxypropyl)methacrylamide copolymer doxorubicin] First member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin. Cancer Res. 5(l) 83-94. 1999. 

In addition to the polymer-only studies, combined drug-polymer coatings were examined in animal models. These early DES coatings showed little or no difference in the inhibition of neointimal proliferation versus BMS. Some of these studies are listed in Table 3. The lack of success of these early studies could be attributed to many reasons, including suboptimal manufacturing processes, lack of desirable... 

A number of randomized clinical trials (RCTs) have investigated stent-based delivery of paclitaxel. These studies utilized a number of different delivery methods, including polymeric sleeves, nonpolymeric drug delivery and from drug-polymer coatings on stents. 

The physical state of the drug incorporated in a powder drug delivery system (e.g., degree of crystallinity and possible interactions with the polymer) is assessed by differential scanning calorimetry (DSC) or Fourier transform infrared (FTIR) spectroscopy. These observations can clarify the results of other parameter investigations, especially the results of in vitro drug release studies. 

Pignatello, R. Eerro, M. Puglisi, G. Preparation of solid dispersion of nonsteroidal anti-inflammatory drugs with acryhc polymers and studies on mechanisms of drug-polymers interactions. AAPS Pharm Sci Tech 2002,5, 1-11. 

Vasey, P. Kaye, S.B. Morrison, R. Twelves, C. Wilson, P. Duncan, R. Thomson, A.H. Murray, L.S. Hilditch, T.E. Murray, T. Burtles, S. Fraier, D. Frigerio, E. Cassidy, J. Phase I clinical and pharmacokinetics study of PKl (iV-(2-hydroxy propy l)methacrylamide copolymer doxorubicin) first member of a new class of chemotherapeutic agents - drug-polymer conjugates. Chnical Cancer Research 1999, 5, 83-94. 

Sastre, R.L. Blanco, M.D. Gomez, C. Socorro, J.M. Teijon, J.M. Cytarabine trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels drug delivery studies. Polym. Int. 1999, 48, 843-850. 

Goracinova K, Klisarova L, Simov A, et al. Preparation, physical characterization, mechanisms of drug/polymer interactions, and stability studies of controlled-release solid dispersion granules containing weak base as active substance. Drug Dev Ind Pharm 1996 22(3) 255-262. 

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