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Drug disposition activity

Lien, E. J., Structure-activity relationships and drug disposition, Anna. Rev. Pharmacol. Toxicol. 1981,... [Pg.460]

Unchanged passive diffusion and no change in bioavailability for most drugs l Active transport and i bioavailability for some drugs l First-pass extraction and T bioavailability for some drugs i Volume of distribution and T plasma concentration of water-soluble drugs T Volume of distribution and T terminal disposition half-life (t ) for fat-soluble drugs... [Pg.969]

Currently available arrhythmic drugs were developed at a time when the molecular basis of cardiac arrhythmias was not understood. Thus, therapy has been largely empiric, efficacy has been unpredictable, and serious side effects have been common. Some of variability in clinical action of antiar-rhythmic drugs can be attributed directly to variable drug disposition, through specific pathways whose activity is now well recognized to be modulated by common DNA polymorphisms. [Pg.216]

IV. RAMIFICATIONS OF ALTERING P-gp ACTIVITY EFFECTS ON DRUG DISPOSITION AND DDIs... [Pg.382]

See other pages where Drug disposition activity is mentioned: [Pg.496]    [Pg.502]    [Pg.504]    [Pg.70]    [Pg.668]    [Pg.557]    [Pg.159]    [Pg.193]    [Pg.344]    [Pg.330]    [Pg.41]    [Pg.42]    [Pg.64]    [Pg.71]    [Pg.200]    [Pg.188]    [Pg.192]    [Pg.208]    [Pg.48]    [Pg.382]    [Pg.58]    [Pg.64]    [Pg.21]    [Pg.37]    [Pg.304]    [Pg.243]    [Pg.30]    [Pg.119]    [Pg.203]    [Pg.225]    [Pg.152]    [Pg.135]    [Pg.359]    [Pg.361]    [Pg.363]    [Pg.371]    [Pg.375]    [Pg.608]    [Pg.616]    [Pg.475]    [Pg.707]    [Pg.77]    [Pg.939]    [Pg.3965]    [Pg.138]   


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Active drug

Drugs activity

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