Drug Design Targeting Fungi

In recent years, the incidence and severity of human fungal infections have increased dramatically. The use of powerful immunosuppressive agents for cancer chemotherapy and for organ transplant, combined with the AIDS epidemic, has led to this significant increase. However, in healthy individuals, a normally functioning immune system tends to ward off fungal infections. 

Ergosterol biosynthesis inhibitors, via 14a-demethylase enzyme inhibition 

Of these five targets, those that involve membrane biochemistry (targets 1 ) have proven to be the most successful. 

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