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Drug design ruthenium complexes

The metal ruthenium possesses several favorable chemical properties and it may be a strong candidate to form a basis for rational anticancer drug design [104,105]. For instance, several ruthenium(II) and ruthenium(III) complexes (Scheme 5.5) exhibit a high antitumor activity both in vitro and in vivo [2,106,107]. Therefore, the reactions of Ru and Ru complexes with DNA and sulfur-containing amino acids as well as proteins has been studied by NMR and other spectroscopic methods (e.g. HPLC). Such studies may facilitate the development of an additional structure-activity relationship and allow more selective, potent and less toxic anticancer drugs to be designed. [Pg.187]

See other pages where Drug design ruthenium complexes is mentioned: [Pg.2]    [Pg.6]    [Pg.23]    [Pg.32]    [Pg.33]    [Pg.57]    [Pg.58]    [Pg.667]    [Pg.136]    [Pg.179]    [Pg.39]    [Pg.126]    [Pg.445]    [Pg.16]    [Pg.50]    [Pg.57]    [Pg.49]    [Pg.65]    [Pg.266]   
See also in sourсe #XX -- [ Pg.12 ]



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