Drug compounds alprazolam

Active components in grapefruit juice include furanocoumarins capable of inhibiting the metabolism of many drugs, including alprazolam, atorvastatin, cisapride, cyclosporine, and midazolam. Such compounds may also enhance oral bioavailability by inhibiting drug transporters in the Gl tract responsible for intestinal efflux of drugs,... 

The structures of the drugs used as a small test set for the model are listed in Table 17.1. Loperamide and asimadoline are P-gp substrates terfenadine and ebastine are compounds that are rapidly metabolized alprazolam, dobazam, di-and mono-hydroxy-L66858 [11] are benzodiazepines testosterone and corticosterone are hormones and cefadroxyl, cefaclor, cephalotin and cefmetazole are cephalosporins [12]. Finally, peptides 1 to 10 are peptidomimetic drugs [13]. 

The triazolobenzodiazepines alprazolam (19a) and triazolam (19b) are widely used psychotropic drugs. These compounds are also specific inhibitors of PAF-induced human platelet aggregation with respective IC50 values of ca. 5 and 3 /rM [117], rabbit platelet aggregation with IC50 values of 2.5 and 0.6 [166], and [3H]PAF receptor binding on human platelets (IC50... 

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