Dose-response trials

A typical feature of Phase [lb are dose response trials regarding a drug s safety, efficacy and side effects. No single study design can address all aspects of dose response relationships for a new drug, and so a number of different... 

Treatment of porcine cyticercosis with oxfendazole a dose-response trial. Veterinary Record 141, 420-422. 

Sipila I, Kaitila I, Bland J, Veimo D, Muller J, Mohnike K, Neumeyer L, Ritzen M, Hagenas L. Growth hormone treatment in 35 prepubertal children with achondroplasia a five-year dose-response trial. Acta Paediatr... 

Sang C. N., Booher S., Gilron I., Parada S., and Max M. B. (2002). Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia efficacy and dose-response trials. Anesthesiology 96 1053-1061. 

In a double-blind, placebo-controlled, dose-response trial, 270 acutely agitated patients were randomized to receive 1-3 intramuscular injections of olanzapine (2.5, 5, 7.5, or 10 mg), haloperidol (7.5 mg), or placebo within 24 hours (60). Olanzapine had a dose-related effect in reducing agitation olanzapine was better than placebo but not better than haloperidol the most frequently reported adverse event was hypotension, which occurred with olanzapine (n = 7) but not haloperidol or placebo. Acute dystonias did not occur in patients given olanzapine or placebo but occurred in two patients given haloperidol. 

Garber AJ, Duncan TG, Goodman AM, Mills DJ, Rohlf JL. Efficacy of metformin in type II diabetes Results of a double-blind, placebo-controlled, dose-response trial. Am J Med. 1997 102 491-7. 

Dose-response trials. Response in relation to the dose of a new investigational drug may be explored in all phases of drug development. Dose-response trials serve a number of objectives, of which the following are of particular importance. 

Uthman BM, Rowan AJ, Ahmann PA, Leppik IE, Schachter SC, SommerviUe KW, Shu V. Tiagabine for complex partial seizures a randomized, add-on, dose-response trial. Arch Neurol 1998 55(l) 56-62. 

Marks R, et al. Imiquimod 5% cream in the treatment of superficial basal cell carcinoma results of a multicenter 6-week dose-response trial. J Am Acad Dermatol 2001 44 807. 

Kendall, C.W.C., Jenkins, D.J.A., Marchie, A., Ren, Y., Ellis, P.R., and Lapsley, K.G., Energy availability from almonds implications for weight loss and cardiovascular health. A randomized controlled dose-response trial, EASES J., 17 (Abstract), A339, 2003. 

Foord RD (1967) A multicentre dose-response trial with cephaloridine. Postgrad Med J 43 63... 

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