Structure-activity relationship dose response assessment

Narotsky, M.G., Francis, E.Z. and Kavlock, R.J. (1994) Developmental toxicity and structure-activity relationships of aliphatic adds, induding dose-response assessment of valproic add in mice and rats. Fundam. Appl. Toxicol., 22 (2), 251-265. 

Quantitative Stmcture-Activity Relationships (QSARs) are estimation methods developed and used in order to predict certain effects or properties of chemical substances, which are primarily based on the structure of the substance. They have been developed on the basis of experimental data on model substances. Quantitative predictions are usually in the form of a regression equation and would thus predict dose-response data as part of a QSAR assessment. QSAR models are available in the open literature for a wide range of endpoints, which are required for a hazard assessment, including several toxicological endpoints. 

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