Pharmacodynamics dose ratio

Pharmacokinetic/pharmacodynamic modeling indicates that the AUC/MIC ratio is predictive of outcome for this antibacterial suggesting that telithromycin is suitable for short-duration therapy and a once-daily dosing regimen even against / -lactam and macrolide-resistant pathogens... 

Ethnic Background. It is known that Chinese subjects are more responsive than white subjects to the same dose or plasma concentrations of racemic propranolol. A study [65] investigated whether this could be attributed to higher (—) (-I-) AUC ratios in Chinese subjects, compared with the ratio in the white population. Although the plasma concentrations of both enantiomers were substantially lower in Chinese volunteers, the ratio was the same in both populations [65], suggesting a pharmacodynamic difference in these two populations with regard to the beta-blockade effect. 

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