Dopamine renal dysfunction

Bellomo R. Chapman M, Finfer S, Hickhng K, Myburth J Low-dose dopamine in patients with early renal dysfunction a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Chnical Trials Group. Lancet 2000 356 2139-2143. 

Memoli B, De Nicola L, Libetta C, Scialo A, Pacchiano G, Romano P, Palmieri G, Morabito A, Lauria R, Conte G, et al. lnterleukin-2-induced renal dysfunction in cancer patients is reversed by low-dose dopamine infusion, Am J Kidney Dis 1995, 26 27-33 Palmieri G, Morabito A, Lauria R, Montesarchio V, Matano E, Memoli B, Libetta C, Rea A, Merola C, Correale P, et al. Low-dose dopamine induces early recovery of recombinant interleukin-2-impaired renal function, EurJ Cancer 1993,29A 1119-1122... 

Furthermore, tolerance to the vasodilatory effects of dopamine after 24 to 48 hours is evident in nonohguric patients with sepsis syndrome and has been reported in others. The lack of response to dopamine in septic shock patients on vasopressors and the tolerance that develops in responders to low-dose dopamine may be explained in part by time- and disease-dependent desensitization of the dopamine receptors this may not occur in those with sepsis syndrome or normal volunteers. Furthermore, differences in the extent of preexisting vasodilation and the pathophysiology of renal dysfunction in oliguric and septic shock patients also may contribute to the inconsistent responses seen to the administration of low doses of dopamine. 

ANZICS Clinical Trials Group. Low-dose dopamine in patients with early renal dysfunction a placebo-controlled randomised trial. Lancet 2000 356 2139-2143. 

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