Dopamine in brain tissue

The problem with the silylation of different biogenic amines is that it is difficult to prepare uniform derivatives as these compounds usually contain amino groups of different reactivity, hydroxyl and other functional groups. Several procedures have been proposed for solving this problem. The determination of norepinephrine and dopamine in brain tissue was described by Maruyama and Takemori [90]. Dried residue from the extraction... 

Another biomedical example of modern voltammetry is a rapid scan cyclic voltammetric technique that has been used to quantify dopamine in brain tissue of freely moving animals. In this application, oxidation of dopamine to a quinone species at an implanted microcarbon electrode (at approximately -i0.600 V vs. Ag/AgCl) yields peak currents proportional to dopamine levels. The electrode can be used to measure this neurotransmitter in different regions of the brain or in a frxed location. Often, pharmacological or electrical stimulation can be employed to measure the... 

---