Dopamine antitumor activity

Regarding the pharmacological effects of theanine, previous reports have indicated a reduction in blood pressure in spontaneously hypertensive rats, a relief from convulsions induced by caffeine, and an influence on the brain levels of norepinephrine, serotonin, 5-hydroxyindoleacetic acid, and dopamine. Moreover, oral intake of theanine results in the generation of a-electric waves in the occipital and parietal regions of the human brain Theanine-induced inhibition of glutamate transporter enhances the activity of an antitumor agent. It increased doxorubicin (DOX)-induced antitumor activity, and confirmed that this action contributed to the increase in the DOX concentration in a tumor with inhibition of the DOX efflux from tumor cells. ... 

It has been shown that theanine has numerous health effects, ranging from prevention of neuronal death to reduction of tumor growth, enhancement of antitumor activity of chemotherapeutic agents, and reduction of hypertension and blood pressure. Moreover, theanine relieves excitation induced by caffeine ingestion and influences the brain levels of norepinephrine, serotonin, 5-hydroxyindoleacetic acid, and dopamine. In addition, ethylamine, a major metabolite of theanine, has been found to boost immune response. 

Chemonics International Inc (2001) Biodiversity assessment for Uzbekistan, task order under the biodiversity sustainable forestry. KJC (BIOFOR) USAID contract number LAG-I-00-99-00014-00, submitted to USAID Central Asian Republics Mission, Almaty. http //pdf.usaid.gov/pdf docs/PNACN475.pdf. Accessed 22 Feb 2007 Chen G, Todorov DK, ZeUer WJ (1992) Antitumor activity of thaliblas-tine (NSC-68075) in experimental ovarian tumor cell tines sensitive and resistant to cisplatin. Cancer Lett 62(2) 173—177 Chen B, Teranishi R, Kawazoe K, Takaishi Y, Honda G, Itoh M, Takeda Y, Kodzhimatov OK (2000) Sesquiterpenoids from Ferula kuMs-tanica. Phytochemistry 54(7) 717-722 Chen J, Shi Y, Liu J (2003) Determination of noradrenaline and dopamine in Chinese herbal extracts fiom Portulaca oleracea L. by high-performance liquid chromatography. J Chromatogr A 1003(1-2) 127-132... 

A number of other quinone drugs possess antitumor activity, for example, p-lapachone and those derived from levodopa and dopamine . An oxy radical mechanism for the anticancer action was invoked . 

Biochanin-A is a potent phytoconstituent which has been used in India as an antitumor, a dopaminergic neuron protective agent, an antioxidant, an anticholinergic and a neuroprotectant with antioxidant properties, anticholinesterase activity, and neurotransmitter (noradrenalin, dopamine) enhancing capacity [215]. 

Wick MM 1978 Dopamine a novel antitumor agent active against B-16 melanoma in vivo. J Invest Dermatol 71 163-164... 

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