Dopamine agonists neuroleptic malignant syndrom

Geriatric Considerations - Summary Pramipexole is a nonergot dopamine agonist that directly stimulates dopamine Dj receptors. It can be used in combination wit h le-vodopa or as monotherapy. If discontinued, pramipexole should be slowly tapered because abrupt discontinuation can cause confusion, hallucinations, and a condition similar to neuroleptic malignant syndrome. 

Additive dopaminergic effects would be expected. The serotonin syndrome is thought to occur because of increased stimulation of the 5-HT receptors in the brainstem and spinal cord. A syndrome resembling neuroleptic malignant syndrome (which has similar symptoms to the serotonin syndrome) can occur when a dopamine agonist like bromocriptine is... 

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