Donath, William

Vitamin Bx (Aneurin, Thiamin), das Anti-Beri-Beri-Vitamin wurde im Jahre 1926 von Jansen und Donath (142) aus Reiskleie in krystalli-siertem Zustand isoliert. R. J. Williams (436) zeigte schon 1919, daB verschiedene Heferassen durch Bj-Konzentrate (aus Reiskleie oder Hefe) stark im Wachstum gefordert werden, konnte aber seine Befunde erst einwandfrei bestatigen (440), als ihm reines krystallisiertes Aneurin von Jansen und Donath zur Verfiigung stand. Auch Vera Reader (317), (291) fand, daB zum Wachstum eines Aktinomyceten (Streptothrix corallinus) B Konzentrate erforderlich sind, aber diese behielten nach... 

The pure crystalline vitamin was obtained in Java in 1927 by Barend Jansen and William Donath, who were both students of Eijkman (Jansen and Donath 1927). Robert Williams developed an effective method to isolate vitamin B from rice bran, proposed its structure, and confirmed it by synthesizing the compound (Williams and Cline 1936). The compound, then already given the name vitamin Bi, had a thiazole ring and therefore was named thiamine (Figure 1.1). (As with vitamin , thiamine later lost its e to thiamin , although the spelling thiamine is still frequently used.)... 

In 1926, 6. C. P. Jansen and W. P. Donath, in Holland, isolated the antiberiberi vitamin, and in 1936 Robert R. Williams, an American, determined the structure and synthesized it... 

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