Diabetic gastroparesis domperidone

The mechanism of action and chnical use of domperidone and its specific use in diabetic gastroparesis have been reviewed (5,6). Domperidone is generally well tolerated and has a low incidence of adverse effects. Adverse effects after oral administration include headache, dry mouth, diarrhea, itching, muscle cramps, and anxiety. Galactorrhea, breast tenderness, and pseudopregnancy can occur in women because of a dopamine-induced increase in serum prolactin concentration. 

Systematic reviews The efficacy of domperidone in diabetic gastroparesis has been evaluated in a systematic review of 28 clinical trials in a total of 1016 patients [7 ]. Domperidone improved symptoms, enhanced gastric emptying, and reduced hospital admissions in 60-70% of trials. None of the studies assessed the risk of adverse reactions to domperidone versus comparators. The most common adverse reaction was hyperprolactinemia, but in no case was it serious. 

The efficacy and adverse effects of domperidone and metoclopramide have been compared in a double-bhnd, multicenter, randomized trial in 93 insuhn-dependent diabetics with symptomatic gastroparesis (7). Domperidone 20 mg qds and metoclopramide 10 mg qds, for 4 weeks, were equally effective in alleviating sjmptoms of gastroparesis. Somnolence, akathisia, anxiety, and depression were more... 

Patterson D, Abell T, Rothstein R, Koch K, Barnett J. A double-bhnd multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. Am J Gastroenterol 1999 94(5) 1230-4. 

---