Ketoconazole and domperidone

Mishra H, Polak S, Jamei M, Rostami-Hodjegan A (2014) Interaction between domperidone and ketoconazole toward prediction of consequent QTc prolongation using purely in vitro information. CPT Pharmacometrics Syst Pharmacol 3 el30... 

Boyce MJ, Baisley KJ, Warrington SJ. Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy voltmteers a randomized, placebo-controUed, double-blind, crossover study. Br J Clin Pharmacol 2012 73(3) 411-21. 

Example compounds affecting the adrenal cortex include acrylonitrile, amino-gluthemide, amytriptyline, aniline, carbon tetrachloride (Colby et al. 1994), chloroform, cimetidine, etomidate, domperidone, fluphenazine, glycyrrhizin, ketoconazole (Loose et al. 1983), methanol, parathion, pentabarbitone, phencyclidine, pyra-zole, spironolactone, tamoxifen, and urethane (Colby and Longhurst 1992 Szabo and Sandoz 1997). Amytriptyline and cimetidine reduce corticosterone secretion, whereas pentobarbitone and phencyclidine increase its secretion. Etomidate inhibits 11(3- and 17a-hydroxylating reactions. Spironolactone affects cytochrome P450 enzymes (Kossor et al. 1991), and domperidone blocks cortisol secretion. Some ACAT inhibitors cause adrenal cytotoxicity (Wolfgang et al. 1995). 

A group of nine specific pharmaceuticals from aqueous environmental samples (flubendazole, propiconazole, pipamperone, cinnarizine, ketoconazole, miconazole, rabeprazole, itraconazole and domperidone) was also analyzed with LC-ESI/MS/MS by Van De Steene et al. ... 

---