Domino Reactions Terminated by Reduction Reaction

The Wittig reaction is an ideal procedure for the formation of carbon-carbon double bonds in organic synthesis, which indudes the synthesis of a,P-unsaturated carbonyl compounds [82]. Recently, Williams and coworkers described a domino 

4 Domino Reactions Terminated by Oxidation or Reduction Reaction 315 

A domino hydrometallation/cydization/reduction process was developed for the synthesis of carbocyclic amino alcohols by Gais eX al. Treatment of exocycUc alkenyl sulfoximes 171 with DIBAL-H leads to the hydroaluminated intermediate 172, which subsequently cycUzes to give keto sulfoxyimines 173. 

In this chapter, we presented the importance of oxidation and reduction reactions as part of a domino process in organic synthesis. Particularly, in the synthesis of complex organic molecules, this allows for short, simple, economical, as well as highly selective approaches in which several bonds are formed in one process. Domino reactions initiated by oxidation or reduction reactions have seen enormous growth in the last years. However, the protocols dealing with domino reactions having an oxidation or a reduction in the middle of a reaction sequence or as the terminating step are yet to be explored to their full potential. 

We thank I IT Madras, Chennai, India, for infrastructure facilities. The DST and CSIR (India) are thanked for financial support. I. Karthikeyan and D. Ganapathy thank the CSIR for Senior Research Fellowships. 

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