Domino reactions carbometallation

For domino Heck reactions the initial carbometallation step must lead to intermediates that do not readily undergo /1-hydride elimination and can thus serve as starting points for additional Pd-mediated transformations [7]. Such processes, as exemplified in Scheme 6, have been used extensively by de Meijere, Grigg, Overman and others for assembly of complex carbon skeletons. 

Scheme 10.135 Rhodium-catalyzed domino carbometallation followed by Heck-type crosscoupling reaction in water [113].

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