Gold catalysts domino reactions

In 2013, another intramolecular hydrosilojqrlation was combined with a Mukaiyama aldol condensation by Gong et al. in an enantioselective relay catalytic cascade. This domino reaction occurred between atylacetylene silanols and glyoxylates and was induced by a combination of an achiral gold catalyst and a chiral N-triflyl phosphoramide. As shown in Scheme 7.37,... 

Oxabicyclo[3.2.1]oct-3-ene derivatives can be prepared by a gold(I)-catalyzed cycloaddition reaction of alkynes with oxoalkenes (Scheme 9) (13CEJ3547). In a similar procedure, a gold(III) catalyst mediates an efficient oxidative domino cychzation—cycloaddition reaction of enyne aldehydes and ketones to give polyfimctionalized tetracyclic ketoethers (Scheme 10) (13CEJ14787). 

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