Domino Cycloadditions in Parallel Fashion

As shown in Table 9.3, both (hetero) aromatic and aliphatic R substituents can be introduced via the Knoevenagel condensation. In a parallel fashion, ethyl vinyl ether (10) and styrene (74) reacted with the resin-bound nitroalkenes 73a-e at a pressure of 15 kbar for 20 h (50 °C), after which the resin-bound domino adducts 75a-e were formed (Scheme 9.30). After the domino [4 + 2j/ [3 + 2] cycloadditions... 

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