Domino cobalt catalysts

In summary, we have summarized representative examples of transition-metal-catalyzed carbonylative domino reactions. In the area of carbonylations, palladium, rhodium, and cobalt are still the main actors. The abihty of palladium catalysts in carbonylative cross-coupling, rhodium catalysts in carbonylative C-H activation, and cobalt catalyst in carbonylative reactions with unsaturated bonds is impressive. 

A broad range of olefins, acetals, epoxides, alcohols, and chlorides were demonstrated effective alternative starting materials. Cobalt and rhodium carbonyls and bimetallic complexes catalyzed the domino hydroformylation-amidocarbonylation of olefins (17-22). Addition of 0.1 mol% RheCCOie to the cobalt catalyst gave branched AT-acetyltrifluorovaline, which indicated that the hydroformylation step governs the regioselectivity of the domino process (Scheme 4) (22). 

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