Domino and Tandem Processes Initiated by a Michael Reaction

5 Domino and Tandem Processes Initiated by a Michael Reaction 

In spite of the explosive growth of enantioselective organocatalysed domino reactions in the last decade,an increasing number of enantioselective metal-catalysed domino processes have been developed in the last few years. A domino reaction has been defined by Tietze as a reaction which involves two or more bond-forming transformations, taking place under the same reaction conditions, without adding additional reagents and catalysts, and in which the subsequent reactions result as a consequence of the functionality 

In 2010, Arai et al investigated a catalytic asymmetric exo -selective virtual [3 + 2] cycloaddition of imino esters with trans-nitroalkenes. Usually, when 

Domino Michael/Henry reaction of cyclohexane-1,2-dione with nitroalkenes catalysed by an in situ generated bisoxazolidine nickel catalyst. 

During the last 10 years, an important number of novel, highly efficient asymmetric conjugate additions of various nucleophiles to a wide variety of acceptor-activated alkenes has been developed on the basis of asymmetric 

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