Do Polymorphic Compounds Make Good Co-crystallizing Agents

7 Do Polymorphic Compounds Make Good Co-crystal I izing Agents [107]  

Three of the four polymorphic compounds examined in this study [107] readily form co-crystals e.g. 2-hexeneoic acid isonicotinamide, 2-amino-5-nitropyrimi-dine 2-amino-3-nitropyridine, and 3-dimethylaminobenzoic acid 4-chlorobenza-mide. The structural behavior of 1-3 supports the suggestion that polymorphs make good co-crystallizing agents (provided that solubility differences are not too large). However, no co-crystals with maleic hydrazide were obtained, despite the fact that it exists in three different polymorphs. 

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