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DNA cleavage, by antitumour

The allylic radical (124) has been characterized by ESR as an intermediate in the photolysis of the deoxyribose phosphate (122), a model system for DNA cleavage by antitumour antibiotics (Scheme 18).282 The proposed mechanistic pathway follows that... [Pg.167]

The antitumour action of the natural antibiotic bleomycin is thought to involve the aerobic degradation of DNA by the Fe2+-bleomycin complex. In order to probe the mechanism of antitumour action of bleomycin, the 4-ethylamido[5,(2 -thienyl)-2-thiophene] imidazole iron(II) complex was synthesized [129]. It was studied in non-aqueous solution using cyclic voltammetry and showed antitumour activity in vitro, its action causing cleavage of the double helical DNA. [Pg.112]

See other pages where DNA cleavage, by antitumour is mentioned: [Pg.5]    [Pg.243]    [Pg.45]    [Pg.164]    [Pg.345]    [Pg.201]    [Pg.138]    [Pg.161]    [Pg.95]    [Pg.179]   


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Antitumour

DNA cleavage

DNA cleavage, by antitumour Subject

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