DNA Bases, Nucleotides, and Their Derivatives

Not only can changes in orientation be studied and rationalized using SERS measurements but also the relative proportion of adsorbates can be determined. Watanabe and coworkers have studied potential-dependent changes in the spectra of adenosine, cytidine, and their mixtures among other derivatives of these nucleosides on Ag surfaces [221]. Cytidine displays weaker intensities than adenosine 

SERS peaks also undergo shifts in posihon with electrode potenhal (Stark shift see Section 6.3). The extent of this Stark shift is often related to the charge transfer 

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