Ligand libraries diversity-based

Scheme 6a. Diversity-based approach to iron-based enantioselective catalysts - the ligand library used for catalyst discovery.

Historically, ligand structure-based design has been the most widely used approach to the design of target-directed chemical libraries. Methods that start from hits or leads are among the most diverse, ranging from 2D substructure search and similarity-based techniques to analysis of 3D pharmacophores and molecular interaction fields (Fig. 15.2). 

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