Diuretics excretions patterns

The table below shows the urinary excretion patterns of electrolytes of diuretic drugs. For each of the diuretic agents listed below, choose the urinary excretion pattern that the drug would produce. 

The answers are 373-d, 374-c, 375-a. (Kut ung, pp 253— 254, 256-257.) The urinary excretion pattern of electrolytes for the thiazide diuretic agents (e.g., hydrochlorothiazide) shown in the table that accompanies the question is represented by choice a. These drugs block the reabsorption of Na and Cl at the early distal convoluted tubule of the nephron. In addition, they promote the excretion of K and Mg. At high doses, the thiazide diuretics (especially hydrochlorothiazide) may cause a... 

The complexity of the changes of amiloride-binding site density, and hence presumably of sodium channels, which can take place in these epithelia are only just beginning to be understood. It is not surprising, therefore, that the ideal diuretic has not been found, for any perturbation at one part of the nephron is likely to affect the ambient sodium concentration at a distal part. The ensuing adaptive changes, plus the influence of hormones, are such as to produce complex patterns of excretion. 

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