Thioacylation dithioesters

Fluorinated dithioester 39 has also been involved in thioacylation reaction of enantiopure aminoalcohols leading to the corresponding hydroxylated thioamides. The later, treated either by SOCVpyridine, CH3SO2CI, or PhjP/DEAD, cyclise into thiazolines 42 without epimerisation and in excellent yields. An interesting application of this reaction is the synthesis of a new type of modified nucleotides such as 43 and 44 by a one pot reaction simply by mixing the dihydroxy substituted thioamide (obtained from 39 and the 2-amino-l,3-... 

Peptide dithioesters have been used as model compounds to study the conformations of dithioacyl enzyme complexes. 1 3 Dithioesters are also used as thioacylating agents that introduce the thioamide bonds into the peptide backbone in order to study the structures of endothiopeptidesJ4,5 ... 

Thioacylation of Alcohols and Phenols with Anhydrides, Thiokeienes, Thioesters and Dithioesters... 

Thioacyl diphenylthiophosphinyl sulfides are useful thioacylating reagents too, which give dithioesters in good yields under mild reaction conditions (equation 60). ... 

E. Rizzardo, S. H. Thang and G. Moad Synthesis of Dithioester Chain-Transfer Agents and Use of Bis(thioacyl) Disulfides or Dithioesters as Chain-Transfer Agents in Radical Polymerization CSIRO, W09905099, 1999. 

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