Diteipene alkaloids

The use of acylnitiene cyclizations in the synthesis of diteipene alkaloids goes back to the early 1960s, and although much of the early work has been reviewed, selected examples are included here. The acyl azide (19), readily prepared from podocarpic acid, was irradiated to give the 8-lactam (20 20%), which has the azabicyclononane ring system of the diteipene alkaloids such as atisine. ... 

Zyuzkov GN, Krapivin AV, Nesterova YV, Povetieva TN, Zhdanov W, Suslov NI, et al. Mechanisms of regeneratory effects of Baikal aconite diteipene alkaloids. Bull Exp Biol Med 2012 153(6) 847-51. 

Four basic skeletal types of kaurene-derived diteipene alkaloids are known the atisine, heteratisine, lycoctonine, and veatchine types. 

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