Disulfide chemistry

Carbon disulfide chemistry is thoroughly described in several pubHcations, which include many references (15,25—28). Several important reactions ate mentioned here. 

Carbon disulfide chemistry is thoroughly described in several publications which include many references. 

Note that the equilibrium constants describing the formation of library members from their building blocks is not always chemically realistic. For example, in disulfide chemistry the conversion of thiols into disulfides is an irreversible process. However, treating this process as a fictitious equilibrium is equivalent to going through a series of more chemically realistic exchange steps and mathematically much simpler to deal with. 

Weissman and Kim (WK) [84-87], who used pH changes (acid quenching) to disrupt the folding reaction. The most glaring difference between the two series of studies is that WK showed that, in the productive pathway, only native intermediates play a significant role. Non-native intermediates may only be involved as required by disulfide chemistry in the last stages of folding of BPTl that is, they play a role in the formation of the precursor [30-51 5-55] from [30-51 14-38] (denoted by and iV, respectively). 

Double PPM of Thiolactone-Containing Polymers Combined with Disulfide Chemistry... 

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