2,3-Disubstituted pyrrolo pyridines

Dipole moments for several mono- and disubstituted pyrrolo[2,3-3]pyridines, 26, have been calculated using the PM3 method <1997JFA2345>. The values range from approximately 1 D for 3-halo-substituted compounds to 5.14 D for the 3-nitro deriv ative (see Table 1, Section 10.06.2.2). 

Several 2,3-disubstituted pyrrolo[2,3-fe]pyridines (7-azaindoles) 24 have been obtained with high regioselectivity by Pd-catalyzed heteroannulation of alkynes with 2-amino-3-iodopyridine derivatives under the experimental conditions shown in Scheme 14 (1998TL627). The easy manipulation of substituents was also demonstrated. 

The /V-acyl compounds are very suitable for the synthesis of pyrrolo[3,4-b]pyridines (10). As a rule, these compounds are synthesized starting from 2,3-disubstituted pyridines (69BCJ2996 75CB1003 77CCC283). Only a... 

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