Distance in property space

The one-dimensional reaction coordinate was constructed by compilation of 15 properties for each conformation within a trajectory chosen properties were native and nonnative contacts, radius of gyration, end-to-end distance, fraction of a-helix and -sheet content, and various SASA measures.The properties are normalized and then used to calculate a distance in property space between each individual conformation in an unfolding trajectory, /, and that of a structure from a reference ensemble, /, such as the native state ensemble. The distances in the 15-dimensional property space, dp p, were calculated using... 

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