Dissipation of Performance Reference Compounds PRCs

In order to assess an analyte s in situ SPMD-water exchange kinetics, performance reference compounds (PRCs as described in Chapter 1) are added to SPMD triolein prior to an exposure (Ellis et al., 1995 Booij et al., 1998 Ockenden et al., 2001 Huckins et al., 2002a). To use this approach, the investigator must be 

When the k and SPMD-water partition coefficient of the PRC are known, its Rs can be calculated from Eq. 3.20. More precisely, we assume that the PRC is representative of the in situ sampling rates of target compounds with similar physicochemical properties as the PRC. Various approaches have been used to estimate sampling rates for all analytes from the PRC-derived sampling rates (see Section 3.6.). 

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