Disseminated intravascular coagulation pathophysiology

Francini M. Pathophysiology, diagnosis and treatment of disseminated intravascular coagulation An update. Clin Lab 2005 51(11—12) 633—639. 

Ono, S Mochizuki, H., and Tamakuma, S A clinical study on the significance of platelet-activating factor in the pathophysiology of septic disseminated intravascular coagulation in surgery. Am. J. Surg. 171,409-415 (1996). 

Pathophysiologically, there is little difficulty in recognizing disseminated intravascular coagulation and then treating this on merit. Much more frequent are immunologically mediated mechanisms that may be secondary to underlying collagen-vascular diseases such as systemic lupus erythematosus or where the defect exists in isolation and the process is defined as primary, idiopathic or autoimmune. 

Pathophysiologically, accelerated breakdown of fibrin occurs secondarily to disseminated intravascular coagulation or primarily in prostatic surgery. 

Bick RL. Disseminated intravascular coagulation Current concepts of etiology, pathophysiology, diagnosis, and treatment. Hematol Oncol Clin North Am 2003 17 149-176. 

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