Disruption of association

In the below described experiments, the adamantyl substituted poiy[7V-tris (hydroxymethyl) methyl] acrylamide (poiymer A) and P-CD polymer were used as two self-associating water soluble polymers, and the drug naproxen served as a blocker of their association [25]. Polymer A substituted with adamantyl units and P-CD polymer obtained by crosslinking with EP were mixed to give an inciusion complex in the form of a gei. Upon introduction of a drug molecule, e.g. naproxen which is able to fill the P-CD cavities, the expulsion of adamantyl unit occurs this behavior leads to disruption of association of polymer A with P-CD polymer, and to inhibition of the gel formation. 

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